Abstract

Brief Communication

Left ventricular hypertrophy linked with arterial hypertension through centralized aerobic-anaerobic energy balance compensation theory

Kirill V Zhukov, Bagrat A Gasparyan, Alexandre A Vetcher* and Alexander Y Shishonin

Published: 26 October, 2022 | Volume 6 - Issue 1 | Pages: 012-014

We demonstrated intrinsic connections between left ventricular hypertrophy (LVH) and arterial hypertension (AHT) through the recently announced centralized aerobic-anaerobic energy balance compensation (CAAEBC) theory. CAAEBC has already demonstrated achievements in the treatment of AHT, diabetes myelitis (DM), and osteochondrosis. Such demonstration lifts the necessity to check the applicability of this theory to other non-communicable diseases (NCDs) and develop the proper way to model the main idea of CAAEBC.

Read Full Article HTML DOI: 10.29328/journal.ach.1001030 Cite this Article Read Full Article PDF

Keywords:

Left ventricular hypertrophy; Arterial hypertension; Centralized aerobic-anaerobic energy balance compensation theory

References

  1. Bornstein AB, Rao SS, Marwaha K. Left Ventricular Hypertrophy. Treasure Island (FL): StatPearls Publishing; 2022.
  2. Cuspidi C, Sala C, Negri F, Mancia G, Morganti A; Italian Society of Hypertension. Prevalence of left-ventricular hypertrophy in hypertension: an updated review of echocardiographic studies. J Hum Hypertens. 2012 Jun;26(6):343-9. doi: 10.1038/jhh.2011.104. Epub 2011 Nov 24. PMID: 22113443.
  3. Kahan T, Bergfeldt L. Left ventricular hypertrophy in hypertension: its arrhythmogenic potential. Heart. 2005 Feb;91(2):250-6. doi: 10.1136/hrt.2004.042473. PMID: 15657259; PMCID: PMC1768675.
  4. Aronow WS. Hypertension and left ventricular hypertrophy. Ann Transl Med. 2017;5(15):310. doi: 10.21037/atm.2017.06.14.
  5. Whelton PK, Einhorn PT, Muntner P, Appel LJ, Cushman WC, Diez Roux AV, Ferdinand KC, Rahman M, Taylor HA, Ard J, Arnett DK, Carter BL, Davis BR, Freedman BI, Cooper LA, Cooper R, Desvigne-Nickens P, Gavini N, Go AS, Hyman DJ, Kimmel PL, Margolis KL, Miller ER 3rd, Mills KT, Mensah GA, Navar AM, Ogedegbe G, Rakotz MK, Thomas G, Tobin JN, Wright JT, Yoon SS, Cutler JA; National Heart, Lung, and Blood Institute Working Group on Research Needs to Improve Hypertension Treatment and Control in African Americans. Research Needs to Improve Hypertension Treatment and Control in African Americans. Hypertension. 2016 Nov;68(5):1066-1072. doi: 10.1161/HYPERTENSIONAHA.116.07905. Epub 2016 Sep 12. PMID: 27620388; PMCID: PMC5063700.
  6. de Simone G, Mancusi C, Esposito R, De Luca N, Galderisi M. Echocardiography in Arterial Hypertension. High Blood Press Cardiovasc Prev. 2018 Jun;25(2):159-166. doi: 10.1007/s40292-018-0259-y. Epub 2018 May 2. PMID: 29721914.
  7. Finocchi C, Sassos D. Headache and arterial hypertension. Neurol Sci. 2017 May;38(Suppl 1):67-72. doi: 10.1007/s10072-017-2893-x. PMID: 28527058.
  8. Wermelt JA, Schunkert H. Management of arterial hypertension. Herz 2017;42(5): 515–26.
  9. Ermoshkin VI. Hypothesis of causeless hypertension. (in Russian) http://www. medlinks.ru/, 2011.
  10. Vetcher AA, Zhukov KV, Gasparuan BA, Shishonin AY. The cerebellum role in arterial hypertension. Medical Hypotheses. 2022;162:10835 doi:10.1016/j.mehy.2022.110835
  11. Vetcher AA, Zhukov KV, Gasparuan BA, Shishonin AY. The cervical blood flow parameters with the best correlation from arterial blood pressure in hypertension cases. International Journal of Recent Scientific Research. 2021; 09 (A):42957-42958 doi:10.24327/ijrsr.2021.1209.6184
  12. Vetcher AA, Zhukov KV, Gasparuan BA, Shishonin AY. Restoration of HbA1c level for pre-diabetic patients through the restoration of arterial blood flow access to rhomboid fossa. 2022; 3: 470–476. Doi: 10.3390/diabetology3030035
  13. Zhukov KV, Vetcher AA, Gasparuan BA, Shishonin AY. Alteration of Relative Rates of Biodegradation and Regeneration of Cervical Spine Cartilage through the Restoration of Arterial Blood Flow Access to Rhomboid Fossa: A Hypothesis. Polymers (Basel). 2021 Dec 3;13(23):4248. doi: 10.3390/polym13234248. PMID: 34883749; PMCID: PMC8659970.
  14. Franz IW, Tönnesmann U, Müller JF. Time course of complete normalization of left ventricular hypertrophy during long-term antihypertensive therapy with angiotensin converting enzyme inhibitors. Am J Hypertens. 1998 Jun;11(6 Pt 1):631-9. doi: 10.1016/s0895-7061(98)00024-7. PMID: 9657621.
  15. Aronow WS, Ahn C, Kronzon I, Koenigsberg M. Congestive heart failure, coronary events and atherothrombotic brain infarction in elderly blacks and whites with systemic hypertension and with and without echocardiographic and electrocardiographic evidence of left ventricular hypertrophy. Am J Cardiol. 1991 Feb 1;67(4):295-9. doi: 10.1016/0002-9149(91)90562-y. PMID: 1825011.
  16. Drazner MH. The progression of hypertensive heart disease. 2011; 123:327-334. Doi: 10.1161/CIRCULATIONAHA.108.845792
  17. Courtine G, Bunge MB, Fawcett JW, Grossman RG, Kaas JH, Lemon R, Maier I, Martin J, Nudo RJ, Ramon-Cueto A, Rouiller EM, Schnell L, Wannier T, Schwab ME, Edgerton VR. Can experiments in nonhuman primates expedite the translation of treatments for spinal cord injury in humans? Nat Med. 2007 May;13(5):561-6. doi: 10.1038/nm1595. PMID: 17479102; PMCID: PMC3245971.
  18. Geissler SA, Schmidt CE, Schallert T. Rodent Models and Behavioral Outcomes of Cervical Spinal Cord Injury. J Spine. 2013 Jul 27;Suppl 4:001. doi: 10.4172/2165-7939.S4-001. PMID: 25309824; PMCID: PMC4191831.
  19. Simon FH, Erhart P, Vcelar B, Scheuerle A, Schelzig H, Oberhuber A. Erythropoietin preconditioning improves clinical and histologic outcome in an acute spinal cord ischemia and reperfusion rabbit model. J Vasc Surg. 2016 Dec;64(6):1797-1804. doi: 10.1016/j.jvs.2015.10.011. Epub 2015 Nov 21. PMID: 26610640.
  20. Uezu T, Koja K, Kuniyoshi Y, Miyagi K, Shimoji M, Arakaki K, Yamashiro S, Mabuni K, Senaha S. Blood distribution to the anterior spinal artery from each segment of intercostal and lumbar arteries. J Cardiovasc Surg (Torino). 2003 Oct;44(5):637-45. PMID: 14735053.
  21. Singh VK, Thrall KD, Hauer-Jensen M. Minipigs as models in drug discovery. Expert Opin Drug Discov. 2016 Dec;11(12):1131-1134. doi: 10.1080/17460441.2016.1223039. Epub 2016 Aug 22. Erratum in: Expert Opin Drug Discov. 2017 Jul;12 (7):755. PMID: 27546211.
  22. Maršala M.Spinal cord blood flow and metabolism in transient spinal ischemia. In: E Stålberg, HS Sharma, Y Olsson, editors. Spinal cord monitoring. New York: Springer. 1998; 5-25.
  23. Pais D, Casal D, Arantes M, Casimiro M, O'Neill JG.Spinal cord arteries in Canis familiaris and their variations: implications in experimental procedures. Braz J Morphol Sci. 2007;24: 224– 228.
  24. DeGirolami U, Zivin JA. Neuropathology of experimental spinal cord ischemia in the rabbit. J Neuropathol Exp Neurol. 1982 Mar;41(2):129-49. doi: 10.1097/00005072-198203000-00004. PMID: 7062084.
  25. National Research Council (US) Committee on Scientific and Humane Issues in the Use of Random Source Dogs and Cats in Research. Scientific and Humane Issues in the Use of Random Source Dogs and Cats in Research. Washington (DC): National Academies Press (US); 2009. 2, Use of Dogs and Cats in Research: Public Perception and Evolution of Laws and Guidelines. 1-9.

Figures:

Figure 1

Figure 1

Similar Articles

Recently Viewed

Read More

Most Viewed

Read More

Help ?